The association between interleukin-4 -590C/T genetic polymorphism, IL-4 serum level, and advanced endometriosis

The association between interleukin-4 -590C/T genetic polymorphism, IL-4 serum level, and advanced endometriosis

AIM OF THE STUDY Aim of the study was to investigate interleukin (IL)-4 serum levels in patients with advanced endometriosis and whether IL-4 promoter region (-590C/T) genetic polymorphism is involved in genetic susceptibility to endometriosis. MATERIAL AND METHODS IL-4 serum levels and IL-4 -590C/T genetic polymorphism were determined for 80 patients with advanced endometriosis and 85 health...

Lack of Association between ctla-4 A49G Polymorphism and Vitiligo

Background: Vitiligo is an acquired skin disorder that selectively destroys melanocytes in epidermis with an unknown etiology.   Objective: To investigate the exon 1 A49G polymorphism of cytotoxic T lymphocyte antigen-4 (ctla-4) gene in vitiligo patients.   Methods: The A49G polymorphism was detected by Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP) method in 101...

Association between Serum IL-4 Levels and Cyst Relapsing in Cystic Echinococcosis

Association between IL-4 gene polymorphisms, IL-4 serum levels, and ankylosing spondylitis.

We aimed to investigate the effect of two common polymorphisms in interleukin-4 (IL-4) on serum IL-4 levels and the development of ankylosing spondylitis (AS) in the Chinese population. A total of 420 inpatients and outpatients diagnosed with AS were enrolled as the case group, and 330 healthy volunteers were selected as the control group. IL-4 rs2243250 and rs2227282 genotype frequencies in th...

Association between Interleukin-8 -251T/A Polymorphism and Endometriosis in Iranian Women

Bachground: Endometriosis is a disease of female genital system, which is defined by the presence of ectopic endometrial tissue outside the uterine cavity. IL-8 is an autocrine growth factor in the endometrium that contributes to the pathogenesis of endometriosis. The aim of this study was to investigate the association between -251T/A polymorphism in the IL-8 gene and endometriosis risk in Ira...